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The Ups and Downs of Tregs and the TNFR2 Receptor; Lessons of Type 1 Diabetes and Chronic Infections


Denise Faustman, MD, PhD
Associate Professor of Medicine, Harvard Medical School
Director of the Massachusetts General Hospital Immunobiology Laboratory

Dr. Faustman completed her internship, residency, and fellowships in Internal Medicine and Endocrinology at the Massachusetts General Hospital and became an independent investigator at the MGH and Harvard Medical School in 1987.  She is a member of the AAAS and serves as a frequent member of the Institute of Medicine in Washington, D.C.

She has spent the last decade researching the nature of the molecular defect in T-cells that results in the development of autoimmunity.  This work led her to discover a novel way to treat diabetic mice, accomplishing for the first time ever, the permanent reversal of established diabetes.  Her earlier research accomplishments include the first introduct of the concept of modifying the antigens on donor tissues to prevent their rejection, a scientific accomplishment that is now in human clinical trials for diverse human diseases treatable with cellular transplants.

Currently, Dr. Faustman is working on strategies for applying this method to treat human disease and to explore the applicability of this process in other autoimmune diseases.  Visit her website to learn more about this research and view recent publications.

Time: 3:30 - 4:30 p.m.
Texas Institute for Preclinical Studies (TIPS) Auditorium